Work

The idea of a study consists in the interdisciplinary collaboration of search of microorganisms producers of proteases, characterization of these proteases, molecular analysis of their action on the molecule of fibrinogen and finally a functional study of the activation of compounds of the fibrinolytic system on these partly hydrolyzed forms of fibrinogen. The performing of the work needs the collaboration between two Institutes of the NAS of Ukraine and the three scientific departments of these Institutions. The result of a project will be the scientific knowledge about the mechanisms of the fibrinolysis regulation, but also the information about centers of interaction of fibrinogen with compounds of fibrinolytic system. Action on the latter will allow to regulate the process of fibrin clot digestion preventing the occlusion of vessels or making stronger the clot that prevents the blood loss.